Daxxify vs Botox: What to Know

The anti-aging landscape is continually changing with the advent of constant innovation. The Global Anti-Aging products market is expected to reach $47.8 billion by 2027.

The broader anti-aging market encompassing cosmetic procedures, dental procedures, and anti-aging medicine is projected to reach $120.4 Billion by 2032.

Monitoring the ever-changing range of products and procedures is important.

Let’s begin by better understanding what Daxxify and Botox are and how they work.

Daxxify vs Botox – How are They Formulated?


Daxxify stands for DaxibotulinumA-lanm or Daxi, a new injectable treatment created specifically targeting frown lines or glabellar lines to deliver a more youthful appearance.

Daxxify employs a peptide exchange technology to precisely deliver the botulinum toxin to nerve cells. Like other products, the action temporarily relaxes moderate to severe lines.

It is also a neuromodulator like Botox, Dysport, Jeuveau, and Xeomin, but it is derived from a peptide instead of a protein.

Daxxify was approved by the FDA for cosmetic use in 2022.


Botox, or Botulinum toxin type A, is a highly purified form of botulinum toxin that temporarily blocks the nerve signals to a muscle, smoothing the affected lines and wrinkles caused by repetitive facial movements.

One of the most significant benefits of this anti-wrinkle treatment is its ability to block acetylcholine release, halting muscle contractions and allowing Botox to target specific muscle activity precisely. This precise targeting is what makes Botox so widely used.

Botox was approved by the FDA for cosmetic use in 2002.

Daxxify vs Botox – Key Differences

  • Botox must be refrigerated, and Daxxify can be kept at room temperature.
  • Botox is approved for a wide range of uses, including the treatment of migraines and excessive sweating. Botox can treat frown lines (glabella lines), forehead lines, and crow’s feet. Daxxify is only approved for use on frown or glabellar lines.
  • Botox generally lasts 3-6 months, and Daxxify can last 6-9 months, but it is important to note that every person is different.
  • Age, genetics, skin type, exposure to sun and pollution, and a healthy lifestyle contribute to how long an injectable lasts. Often, Botox users will experience lasting effects for six months or more; it all depends on the individual.
  • Botox has been used since 2002, making it more widely available and economical as an anti-aging treatment.
  • An important fact to note: Even though these products are of the same class, they are very different and not interchangeable. The other caveat is that their dosages are very different, so seeing a professional for treatment is vital.

Daxxify vs. Botox – Positive Effects on Skin Rejuvenation

Daxxify’s revolutionary peptide exchange may mean the result is a safe and more natural option with longer-lasting results.

On the other hand, Botox’s success in reducing fine lines and wrinkles is well documented since it has been used since 2002, compared to Daxxify’s 2022.

Botox effectively reduces dynamic wrinkles like crow’s feet, horizontal forehead lines, and frown lines for a smoother, more youthful appearance.

Daxxify vs Botox – Potential Drawbacks

While Daxxify is a new product in the anti-aging game, it is promising but has some drawbacks. Being new to the market, there is not a lot of long-term data to draw on. Also, some users may experience bruising, headache, and eyelid ptosis.

Botox has been used for a long time and is well-documented for cosmetic use. Temporary side effects may include bruising, swelling, or muscle weakness at the injection site.

Safety Considerations

  1. If you are pregnant or nursing, you cannot receive either Daxxify or Botox treatments.
  2. If you have a history of allergies, clear any treatment with your doctor first.
  3. Both products are injected using a very fine needle and must be administered by a skilled professional.

The debate over the ultimate winner in the anti-aging game, Daxxify vs Botox, depends on you! Everyone is different. Everyone has different genetics, facial patterns, and different personalities, which all lead to the type and number of facial lines we develop.

Both products offer unique benefits, but ultimately, your personal approach to aging and your goals will be the deciding factor.


The skincare professionals at LightRx are here to help you navigate the anti-aging landscape and design a plan that works to meet your personal needs.

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